NEED TO KNOW
- Grey’s Anatomy season 22 premiered in October 2025
- The medical drama aired its most recent episode in November 2025 before going on a holiday break
- The ABC show returns with new season 22 episodes in January 2026
The staff of Grey Sloan Memorial deserved a break this holiday season.
In October 2025, Grey’s Anatomy returned for season 22, picking up in the aftermath of the devastating explosion that rocked the hospital in the season 21 finale.
The blast injured several and led to the shocking death of a doctor. Following the catastrophic event, Meredith Grey (Ellen Pompeo) and other members of Grey Sloan Memorial began rebuilding while trying to stay hopeful — a theme that will continue throughout the installment.
“One thing that … we’re looking at across the season is a theme of hope,” showrunner Meg Marinis told Shondaland. “It clearly is dashed at the beginning of our season with our destroyed hospital and what’s happened to some of our characters. And so, our characters really need to find hope.”
Grey’s Anatomy season 22 has featured the series’ signature mix of medical drama and emotional relationships. After the most recent episode aired in November 2025, the show is making a highly anticipated comeback.
So, when does Grey’s Anatomy return? Here’s everything to know about the next season 22 episode.
Is Grey’s Anatomy on tonight?
Anne Marie Fox/Disney via GettyYes, Grey’s Anatomy is on tonight, Jan 8.
Season 22 premiered on Oct. 9, 2025, and the latest episode aired on Nov. 13, 2025.
The medical drama recently reached a historic milestone. The second episode of season 22 was the series’ 450th episode, a moment creator Shonda Rhimes spoke about on Today in October 2025.
“I cannot believe that’s what’s happening. That we’ve gone so long that now we’re the longest-running medical show in history,” she said.
Rhimes continued, “To be at 450 is amazing, and really all because of the fans, and the fact that they’ve kept watching the show, and they’ve stuck with it, and they’re excited and invested.”
When does Grey’s Anatomy return in 2026?
Disney/Anne Marie FoxGrey’s Anatomy returns with its midseason premiere on Jan. 8. Season 22, episode 7 is titled “Skyfall.”
A 30-second promo for the upcoming debut shows Jo (Camilla Luddington) under anesthesia in an operating room. Additional crew members then rush in as a baby cries in the background, and alarms on medical equipment begin to sound.
Shortly after, viewers see chest compressions being performed on Jo as Link (Chris Carmack) prays in a church surrounded by candles. In the final seconds, Bailey (Chandra Wilson) tears up while standing next to Richard (James Pickens Jr.).
Is Grey’s Anatomy over?
Anne Marie Fox/DisneyNo, Grey’s Anatomy season 22 isn’t over yet.
The current installment will consist of 18 episodes and with six episodes already aired, 11 remain.
In an April 2025 Variety interview, Pompeo confirmed that she would continue to serve as an executive producer on the series and provide voiceovers for each episode, but she was only contracted to appear in seven episodes on season 22.
As for the Grey’s Anatomy show as a whole, it’s unclear if the alphabet network plans to renew it for a season 23.
Where can I watch Grey’s Anatomy?
Disney via GettyGrey’s Anatomy airs on Thursdays on ABC, and new episodes are available to stream the next day on Hulu.
All 21 of the previous seasons are also available on the streamer.
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